VSL#3 Review: The Best Probiotic Supplement for Gut Health, Bloating and IBS?

In the past I’ve never believed that probiotic supplements should be an essential part of someones daily supplement regime. To me the idea of having the correct balance of ‘friendly bacteria’ never seemed like something that I should take seriously. My view on this has now changed.

Recently I’ve been researching a bit more into my apparent stomach bloating and came across a concept called Leaky Gut Syndrome. I won’t go into the details here, but this sounded like something that I may have been experiencing.

One of the steps to healing leaky gut is to begin taking probiotics. With this in mind I decided I wanted to take a probiotic and didn’t mind paying a higher price for a quality probiotic supplement. This is when I decided to try out VSL#3 probiotics.

What is VSL#3?

VSL#3 is known to have the highest concentration of helpful bacteria; it has 450 billion live bacteria in one packet. The human stomach usually has thousands of billions of bacteria.

For you to regulate the composition of your stomach flora, you will need a big amount of probiotic bacteria. VSL#3 turns out to be the only preparation that offers enough bacteria to help the gut bacteria in people with severe intestinal disorders like Irritable Bowel Syndrome, ulcerative colitis, or ileal pouch.

How Does VSL#3 Work?

VSL# 3 works by supplying the gastrointestinal tract with ideal quantities and types of good bacteria. These bacteria attach to the walls of the GI tract and create a barrier that shields the inner layer of the stomach from pathogenic/bad bacteria and other harmful substances that can lead to inflammation by modulating intestinal defense mechanisms.

It also regulates a number of substances that are associated with inflammation healing. VSL#3 also minimises intestinal fluid flow rate by tightening up all the junctions between the stomach cells in the epithelium. If these spaces between the stomach cells wall enlarge, bad bacteria and toxins can easily flow through, leading to inflammation.

Each dose of VSL#3 contains a combination of 8 live freeze-dried probiotic bacteria namely:

  • Bifidobacterium breve
  • Bifidobacterium infantis
  • Bifidobacterium longum
  • Lactobacillus acidophilus
  • Lactobacillus plantarum
  • Lactobacillus paracasei
  • Lactobacillus bulgaricus
  • Streptococcus thermophilus

It is these particular combination of poly-biotics that can help improve symptoms of bloating and pain..

Why Is VSL #3 One of the Best Probiotic Supplements?

This supplement has the highest CFU count of live bacteria, unlike any other probiotic supplement out there. Their capsules usually have 112.5 billion live lactic acid bacteria, whilst their sachet product contains 450 billion. If you look at most other probiotic supplements they will usually average around 30 billion.

What is the Research into VSL#3?

This product is licensed to be prescribed for pouchitis treatment. This is after several clinical studies with one showing that it can be effective for treating mild pouchitis.

Another study has shown that VSL#3 can offer responses and remissions in patients suffering from mild-to-moderately active ulcerative colitis. The results showed remission in 77% of UC patients with acute effects.

These studies also showed that VSL#3 could help IBS patients and others concluded that it could help mitigate digestive discomfort symptoms.

VSL#3 Product Options

VSL# 3 is a probiotic supplement that is usually marketed under the medical food category. It contains a high-potency enclosed probiotic found in both non-prescription and prescription strengths.

If you are wondering what medical foods are, here is the answer. They are foods that meet 3 basic requirements:

  1. Always required to be taken under a doctor’s supervision
  2. Give a specific nutritional need regarding a certain disease, which is unable to be met by a diet on its own
  3. Is meant for dietary management of a specific disease or condition

This probiotic comes in four options. These products are differentiated by their intake method and the required quantity that they offer. The powder option comes in various flavours and is best consumed after mixing it with water. The different options include:

  • Basic Capsules: these deliver 112.5 billion live bacteria
  • Junior Packets: contain 225 billion of live bacteria
  • Regular Packets: contain 450 billion live bacteria
  • Double Strength Packets: has 900 billion live bacteria and are prescription only

My Experience

I first heard about VSL#3 on a couple of youtube videos mentioning that it was a good probiotic. Another probiotic that frequently popped up was Prescript-Assist. However at the time the listing of Prescript-Assist on Amazon had a lot of warnings from fellow customers that the product being sent out to them was not real. I decided to not take the risk at all and go with VSL#3.

*Later Edit: This problem regarding Prescript Assist appears to now have been fixed on Amazon

Prescript-Assist Soil based Probiotic and Prebiotic- 90 Capsules ( previous formula, no pea protein...
  • The only three official authorized sellers on...
  • Take 1-2 capsules per day ( 620mg/per cap) as a...
  • Viability, the seed-like structure encasing the...
  • Effective for Allergies, bloating, gas,...
  • No refrigeration necessary /shelf stable

Once I had chosen VSL#3 I then had to choose which version to go with. I wanted to take my gut healing diet seriously so I decided to go with the strongest dose and go with that for at least 30 days.

Delivery Needs to be Cold

I ordered straight off the official VSL#3 website as they had a promotion to try out their new ambient delivery service (available in the UK) where there is no need to send the boxes in an ice pack.

VSL#3 Capsules 60 caps (2 pack) Shipped as shown in a cooler with an ice pack.
  • 112.5 billion live lactic acid bacteria per...
  • Highest available concentration of beneficial...

I’ll elaborate on this.

The VSL#3 packets must be kept in the fridge to ensure that the living bacteria remain alive. At too high a temperature they will die, however VSL#3 can be kept out of the fridge for up to 7 days as long as the weather isn’t too hot. If the weather is over 20 degrees they will not send the package out. Since I ordered this in the UK during October, this was not a problem and they sent the package out the day after I ordered.

If you want to buy the VSL#3 packs Amazon.com is a great option because they will ship it to you in a refrigerated ice pack, which means you can order them all year round.

Regarding the packaging, it came well packaged and I got 3 boxes containing 10 sachets each, which I keep in the fridge at all times.


You can take up to 1 to 2 sachets per day mixed in with your food or a cold drink. Personally I went with 2 per day with the plan of going down to 1 per day for a further 90 days and then re-evaluate my dosage then.

The precise dosages are as follows:


  • For IBS, take 2-4 capsules daily or ½ to 1 full packet of powder
  • For Ulcerative Colitis, you should take 4-8 capsules or 1 to 2 powder packets daily
  • For Pouchitis, take 2-4 powder packets daily
  • For Active Ulcerative Colitis, take 4-8 powder packets daily
  • For patients with Active Ulcerative Colitis, their dose may be required to be high, specifically at first.


Always follow the doctor’s advice on the correct dose and frequency of the VSL#3 probiotic formula.

VSL#3 Side Effects

Although I didn’t notice any side-effects here are some that are possible:

  • Consistent urge to visit the toilet that might lead to diarrhoea at first, which is normal
  • Excessive gas and bloating
  • Abdominal pains

Talk to your doctor before taking this supplement. Also, you can try to reduce the dose if abdominal pains become severe.

One important thing to take into consideration is that if you do experience side-effects, it can be a positive sign that your gut is adapting to the new bacteria and is detoxing. So if you are taking VSL#3 and notice these symptoms, don’t automatically assume they are negative signs. Most likely it is a sign that they are working. VSL#3 point out that positive results are usually seen after one month of taking them.

Advantages of VSL #3

  • Optimised for digestive health– this supplement will help any individual with sensitive guts or other inflammatory bowel problems by supplying them with an everyday strengthened increase of strong probiotics to raise digestive capacity and everyday comfort.
  • Super strong– this is one of the strongest probiotics you will find on the market. With 450 billion CFU, it was the first strongest probiotic to be introduced to the market. You can even get a version with 900 billion CFU for every dose.
  • Extensively studied– VSL#3 is one of the few products that have undergone through extensive clinical studies.
  • Free of most allergens– VSL#3 is gluten free, nut free, shellfish free, soy free, and GMO-free. However, it does contain traces of dairy.
  • Even if you don’t have any existing digestive problems, VSL#3’s good bacteria can help balance your gut function leading to proper intake of nutrients.

Disadvantages of VSL#3

Below are four reasons why this might not be the right probiotic for you:

  • Could be too strong– if any product turns out to be too strong for you, you can end up with side effects. This product might make you experience probiotic negative effects.
  • Expensive– VSL#3 is expensive. There is no doubt about it. If you do not have stomach issues or any bloating then you may not need to spend this much on a probiotic supplement.
  • Refrigeration– this probiotic requires refrigeration, which might not be ideal for frequent travellers.
  • Contains trace amounts of dairy– although this product is free of gluten and soy, it has traces of dairy, which could be harmful to those with lactose intolerance.

You can buy VSL#3 from Amazon where you will also get some great reviews from genuine customers who have used this probiotic supplement.

Final Verdict on VSL#3

Since i’ve been taking VSL#3 I have seen considerable improvements in my bloating and I do have a much more naturally flatter stomach since taking them. However, I wouldn’t be confident enough to say that VSL#3 was the sole reasons this happened as I have been supporting my gut health with other new healthy habits during my gut regeneration period. Such habits include eating no processed foods, staying away from gluten, diary, using digestive enzyme supplements at meals and eating smaller amounts of food overall.

That being said, I do feel as though they have played their part somehow. As I said earlier, I do plan to drop my intake to 1 per day for the next 90 days then after that I will evaluate. I would love to take VSL#3 everyday over the long term but the fact that they are quite pricey makes me want to rethink this. What I am likely to do is once the 90 days are up, I will then start taking them once per week just to maintain my gut health.

VSL#3 High Potency Probiotic - UNFLAVORED- 30 Pack
  • VSL#3 is a potent probiotic medical food that...

I do recommend that if you feel you have bad gut health, or suffer from problems such as Irritable Bowel Syndrome or leaky gut, that you take VSL#3 over a period of time to balance out the bacteria in your stomach. I would also not be afraid of the cost as your health is vital to your happiness. Once you see progress, you can either stop or reduce your dose, or even move onto a cheaper probiotic as maintenance.

More than 15% of adults experience Irritable Bowel Movement, making probiotics very important for them. Even when you feel like you have a healthy digestive system, it is advisable to take at least 1billion CFU on a daily basis to prevent any future problems. If you are over 30 years, this is a great product for you.

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